Summary: Myofibroblasts are responsible for scarring during fibrosis. The scar propagates mechanical signals inducing a radical transformation in myofibroblast cell state and increasing profibrotic phenotype. Here. we show mechanical stress from progressive scarring induces nuclear softening and de-repression of heterochromatin. https://www.jmannino.com/deal-alert-Sink-Front-Polymer-Tip-Out-Trays-with-Hinges-flash-find/